An open label pilot study of supraerythemogenic excimer laser in combination with clobetasol spray and calcitriol ointment for the treatment of generalized plaque psoriasis. An open label pilot study of supraerythemogenic excimer laser in combination with clobetasol spray and calcitriol ointment for the treatment of generalized plaque psoriasis. First received: November 10, 2009. Purpose This is a 12-week, open-label, pilot trial evaluating the efficacy and safety of the combination of Clobex spray with excimer laser therapy as the initial treatment of generalized plaque psoriasis, followed by maintenance therapy with topical Vectical. Therapeutic approaches to generalized pustular psoriasis and psoriatic arthritis are discussed separately. Thus, we usually prescribe a topical corticosteroid alone as initial therapy. As an example, one study of excimer laser therapy involved 124 patients with stable mild to moderate plaque psoriasis, of whom 80 completed the entire protocol 74.
Study Finds Excimer Laser Effective For Generalized Psoriasis, Prompts Study Adding Clobetasol And Vitamin D Ointment A study described earlier this year in the Journal of Dermatological Treatment and discussed along with the new study it prompted at the summer AAD in Chicago, offers what its authors consider to be the first solid clinical evidence that a laser can be used to treat generalized psoriasis that covering up to 30 of a patient s body. First Study: Treatment of Generalized Psoriasis with Excimer Laser. Phototherapy can be an effective treatment for generalized plaque psoriasis. A pilot study indicates that the use of XTRAC excimer laser, already proven to be effective in treating mild to moderate cases of psoriasis, is effective in treating patients with moderate to severe psoriasis. The thing that’s unique about this study, though, is that it’s the first study ever conducted where we’re using a laser for not just localized, but generalized, psoriasis. What we are trying to accomplish is to find a way to treat people with generalized psoriasis with absolute systemic safety.
Several new agents to treat psoriasis are under study, including oral medications and injectable agents. Very early results show improvement in plaque psoriasis symptoms for many of these new therapies, but none of them are approved for use yet. Generalized Erythrodermic Psoriasis (also called psoriatic exfoliative erythroderma). Remission rates are similar to those of NB-UVB, but the excimer laser can clear the psoriasis faster and at lower doses. The erythrodermic phase is dominated by generalized erythema and scaling that can be accompanied by an inability to maintain homeostatic functions, a potentially life-threatening complication. Spearheading the study will be Dr. Koo’s colleague, Tina Bhutani, MD. Next News First clinical data for ImmunoGen’s IMGN388 anticancer compound presented at ASCO Annual Meeting.
This chapter will discuss the entire spectrum of phototherapy, including narrowband UVB photo-therapy, broadband UVB phototherapy, PUVA, targeted excimer laser phototherapy, and combination treatments. Dapsone Dermatology Erythematous plaques Genital psoriasis Inverse psoriasis Skin disease. There are few evidence-based studies on the treatment of inverse psoriasis involving genital flexion folds, and data reported related to the efficacy and safety are, so far, extremely limited and only supported by expert opinion (level of evidence 5 and recommendation class D) 1. The evidence-based recommendations suggest the use of weaker topical corticosteroids as a first-line treatment, and vitamin D preparations or tar-based treatments as second-line options 1. Laser therapies (excimer, continuous carbon dioxide, erbium, pulsed dye laser) and UV phototherapy are commonly used for localized skin plaque psoriasis 47 50, except for YAG (yttrium aluminum garnet) laser, which has been shown not to improve localized plaque psoriasis 51.