We describe a patient with acute generalized pustular psoriasis (GPP) treated with the new anti interleukin (IL)-17A antibody, secukinumab, who showed a remarkable response with almost complete resolution of pustulation after the first injection. Complete absence of pustulation was achieved by day 7 (Figure 1B). Generalized pustular psoriasis in pregnancy is also known as impetigo herpetiformis. Erythrodermic psoriasis may develop gradually or acutely during the course of chronic plaque-type psoriasis, but it may be the first manifestation of psoriasis, even in children. View/Print Figure. Figure 1. Scaling plaque in psoriasis affecting the neck. Erythrodermic psoriasis is characterized by widespread generalized erythema and is often associated with systemic symptoms (Figure 3). The localized form of pustular psoriasis consists of pustules on the palms and soles, without plaque formation (Figure 4).
Psoriasis is categorized as localized or generalized, based on the severity of the disease and its overall impact on the patient’s quality of life and well-being. FIGURE 1. Generalized pustular psoriasis (von Zumbusch). 4.4. Figure 4. Erythrodermic psoriasis. Nail changes. Figure 5. Nail changes. 4.6. Figure 1.Psoriasis of the scalp: Figure 2a.Psoriasis of the scalp: Figure 2b. Generalized pustular psoriasis may be provoked by pregnancy and may exacerbate premenstrually, and may also be provoked by high dose estrogen therapy. The morphology of the common chronic stable plaque (psoriasis vulgaris, nummular psoriasis) Erythema which is full, rich red (salmon-pink) to orange-brown –D/D: eczema, seborrheic dermatitis, lichen simplex, lichen planus. –Erythroderma may occur as initial manifestation of psoriasis, or gradually or suddenly developed in a pre-existed psoriasis.
1Division of Dermatology, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. (pustular psoriasis) and generalised erythema and scale (erythrodermic psoriasis). Firstly, chronic plaque psoriasis may gradually progress as plaques become confluent and extensive. Patients with generalised pustular psoriasis frequently need to be admitted to the hospital for management. Psoriasis can manifest itself in several different forms, including pustular and erythrodermic. Figure 1 Involvement of the elbows is characteristic of plaque psoriasis. Figure 7 Erythrodermic psoriasis is characterized by generalized erythema and desquamation. Clinical features of psoriasis vulgaris (chronic plaque psoriasis). Psoriasis vulgaris (Figure 1) is by far the most common presentation.
Treatment Of Psoriasis: An Algorithm-based Approach For Primary Care Physicians
Infantile generalized pustular psoriasis (von Zumbusch) is a rare form of psoriasis. Multiple pustules and excoriations were conspicuous within the erythrodermic and scaly skin. Synonyms: acute generalised pustular psoriasis of von Zumbusch, pustular psoriasis von Zumbusch variant. It is a rare condition: precise prevalence figures for the UK are not available. As the pustules remit, most systemic symptoms ebb but the patient can be left with erythroderma or with residual lesions of ordinary psoriasis. There are recurrent episodes of annular or circinate erythematous plaques, with pustules on the periphery. Erythroderma, or generalized exfoliative dermatitis, is a disease characterized by erythema and scaling of greater than 90 of the body’s surface. Figure 1. Fifteen-years-old girl with diffuse erythema and scaling of lower extremities. Erythematous scaling plaques of the lower extremities. Figure 1. Clinical manifestations of psoriasis. Typical erythematous plaques with silvery scales (A) can be scattered (B, psoriasis nummularis), cover larger areas of the skin (C, psoriasis geographica) or affect the entire body surface (D, erythrodermic psoriasis). Pustular psoriasis, Widespread bright-red erythema studded with 1-2-mm pustules; Pediatric erythroderma is a severe cutaneous disorder, which may pose diagnostic and therapeutic challenges. The diagnosis of psoriasis, already remarkably expressed in the father’s family in three cases of fraternal twins, could be enforced for several points. Erythroderma, together with widespread, refractory plaques, or generalized pustular psoriasis or psoriatic arthritis, are the most severe expressions of the disease, which commonly require systemic treatment.
Psoriasis: Epidemiology, Clinical Features, And Quality Of Life
Psoriatic erythroderma in psoriasis involving the entire skin. The most obvious abnormalities in psoriasis are (1) an alteration of the cell kinetics of keratinocytes with a shortening of the cell cycle resulting in 28 times the normal production of epidermal cells and (2) CD8+ T cells, which are the overwhelming T cell population in lesions. Psoriasis vulgaris: chronic stable type Multiple large scaling plaques on the trunk, buttock, and legs.