Br J Dermatol. 2007 Jun;156(6):1400-1. Family history of psoriasis and age at disease onset in Italian patients with psoriasis. Altobelli E, Petrocelli R, Marziliano C, Fargnoli MC, Maccarone M, Chimenti S, Peris K. Family history of psoriasis and age at disease onset in Italian patients with psoriasis. Psoriasis is often associated with the risk of physical disability, social discomfort and psychological disorders. Pdf Family history of psoriasis and age at disease onset in Italian patients Popular.
Letter from JAMA Internal Medicine Risk of Psoriasis and Obesity in Women. Quality of life in patients with psoriasis: the contribution of clinical variables and psoriasis-specific stress. Family history, smoking habits, alcohol consumption and risk of psoriasis. Psoriasis and psoriatic arthritis (PsA) are clearly complex genetic disorders that result from an interplay between multiple genetic and environmental factors. We stratified PsA patients according to the age of onset of psoriasis (before or after the age of 40 years). Searching for psoriasis susceptibility genes in Italy: genome scan and evidence for a new locus on chromosome 1.
Psoriasis vulgaris has HLA associations. The aim of this study was to determine whether the risk haplotype and Cw6 correlate with the clinical parameters of the disease. The series consisted of 64 patients and the clinical parameters were age at onset, family history of psoriasis, arthritis and the frequency of inpatient treatment. Collecting a set of psoriasis family material through a patient organisation; clinical characterisation and presence of additional disorders. Age of onset varied from the first year of life to 51 years of age. Around 3 reported a history of some neurological disease. Battistel B, Bisighini G, Portioli I: Prevalence of psoriatic arthritis in Italian psoriatic patients. The age of onset and severity of disease varied in family members. Restricting the analysis to 116 trios with a well-documented family history of psoriasis increased the significance of the association for 3 RAPTOR SNPs, with rs2019154 yielding a p value of 0.
Psoriasis is associated with HLA-Cw6, and Caucasians who carry this allele have about a 10-fold increased risk of developing psoriasis. Prevalence of psoriatic arthritis in Italian psoriatic patients. Psoriasis can be a very painful, self-esteem-lowering skin disease. Family history. A positive family history, an association between psoriasis and GT, and the presence of the histocompatibility antigen HLA-Cw6 suggest a genetic basis, providing further evidence that these disorders are related 10. Data on demographic characteristics, habits, medical history, and relevant information on the disease were collected and, according to the age of psoriasis onset, PG were classified as having early (starting before or at the age of 30) or late psoriasis (after the age of 30). Clinical subgroups and HLA antigens in Italian patients with psoriatic arthritis. The onset of the disease before 30 years of age was significantly associated with a higher incidence of family history of psoriasis, a more severe and extensive cutaneous involvement, and greater psychosocial impact. Patients with psoriasis of late onset had a less severe clinical course and a more continuous evolution. Department of Dermatology, and Department of Experimental Medicine: Microbiology and Clinical Microbiology, Second University of Naples, Naples, Italy.