Br J Dermatol. 1994 Nov;131(5):667-72. Erythemal and therapeutic response of psoriasis to PUVA using high-dose UVA. Speight EL(1), Farr PM. Erythemal and therapeutic response of psoriasis to PUVA using highdose UVA on ResearchGate, the professional network for scientists. Erythemal and therapeutic response of psoriasis to PUVA using high-dose UVA. on ResearchGate, the professional network for scientists.
The long-term risks of high dose UVA1 are uncertain so no more than 10-15 treatments per cycle and two cycles per year are recommended. Psoriasis or eczema with thick plaques or affecting palms and soles may resist UVB but respond well to PUVA. Poor response to PUVA can be due to inadequate absorption of the drug or a delay prior to peak levels of psoralen in the skin. We have therefore studied the erythemal and therapeutic response of psoriasis to PUVA using high-dose UVA and, for comparison, the erythemal response to UVB. The erythemal response of uninvolved skin is an important consideration when treating psoriasis as it is this that limits the dose that can be used for treatment; plaques of psoriasis being relatively resistant to becoming more erythematous with UV exposure. Erythemal and therapeutic response of psoriasis to PUVA using high-dose UVA, Br.
Erythemal and therapeutic response of psoriasis to PUVA using high-dose UVA. If there is no erythema, the UVA dosage should be increased at the next session, if there is transient erythema that clears before the next session the UVA dosage should be maintained and if there is persistent erythema from the previous treatment the next session should be cancelled unless the erythema is very minimal and can be protected with clothing or an opaque ointment. Incremental increases in dosage were fixed in the US study and were individualized based on skin response in the European study. High cumulative exposure to oral PUVA is associated with a dose-related increase in the risk of nonmelanoma skin cancer, particularly SCC. PUVA is an ultraviolet light therapy treatment for eczema, psoriasis, graft-versus-host disease, vitiligo, mycosis fungoides, large-plaque parapsoriasis and cutaneous T-cell lymphoma using the sensitizing effects of the drug psoralen. The psoralens allow to lower the dose of the UVA energy. When they are combined with exposure to UVA in PUVA, they are highly effective at clearing psoriasis and vitiligo. It can also be a connection with the skin’s immune response.
Phototherapy. Uva Photo(chemo)therapy. Dermnet Nz
In general, the dose increment in NBUVB depends on erythema response. Conclusion: A thrice-weekly, medium-dose irradiation schedule with the 308-nm laser can effectively clear localized plaque-type psoriasis in fewer treatments with an overall lower cumulative dose, compared with standard phototherapy. Erythemal and therapeutic response of psoriasis to PUVA using high-dose UVA. Treatment with high fluences produced significantly better results than that with medium and low fluences at weeks 4, 6, 8, and 10 (P Figures. Speight ELFarr PM Erythemal and therapeutic response of psoriasis to PUVA using high-dose UVA. Initial dose of treatment is generally 70 of the MED. When they compared response in psoriasis patients treated with an initial dose of 70 of MED followed by 40 dose increments vs. However, incidence of therapy postponement as a result of erythema is higher with PUVA due to the persistent nature of erythema caused by it. Tanning-salon equipment uses UVA light, which does not have nearly as pronounced an effect as UVB (or any effect at all), unless certain drugs called psoralens are either applied topically, or taken orally prior to UVA exposure (a regimen known as PUVA, for Psoralen + UVA ). The association between PUVA and UVA erythemal sensitivity suggests a common pathway in the vascular response induced by UVA radiation, with or without psoralen. Erythemal and therapeutic response of psoriasis to PUVA using high-dose UVA.
The Time-course Of Psoralen Ultraviolet A (puva) Erythema
The use of UVA tanning salon treatments in the therapy of psoriasis is usually unsuccessful and is extremely unwise with concomitant psoralen and drug therapy. A total of 17 patients received 6 whole-body UVB irradiations with 75 of the individually determined minimal erythemal dose after conditioning with a reduced intensity protocol. Patients treated with UVB also had significantly higher 25-hydroxyvitamin D3 serum levels and higher numbers of circulating CD4+ FoxP3+ regulatory T cells.