Epidemiological studies of psoriasis contribute to measuring the public health burden of this disease and guide the care of patients with psoriasis through a better understanding of its natural history. Fundamentals of epidemiologic research include the measurement of occurrence of an event (prevalence and incidence) and the identification of factors that are associated with this event. A number of small, epidemiological studies have reported associations between psoriasis and metabolic syndrome (Al-Mutairi et al. This study significantly advances the existing literature looking at psoriasis and the metabolic syndrome as this is the first population-based study to use objective measures of psoriasis severity, direct measurement of the components of metabolic syndrome and standard criteria for diagnosis of metabolic syndrome. Small increases in the individual components of metabolic syndrome have lead to an 8 absolute increase in the prevalence of metabolic syndrome overall and a 14 increase in those with severe psoriasis. We conducted a cross-sectional study utilizing The Health Improvement Network (THIN).
Over the last two decades my research, teaching and public health practice has addressed effects of interactions of social and biologic experience and population health. Harlow, A longitudinal study of the inception of perimenopause in relation to lifetime history of sexual or physical violence, Journal of Epidemiology and Community Health, in press, 2005. Methotrexate used for psoriasis and the risk of noncutaneous or cutaneous malignancy. Our studies have contributed to measurement discussions (laboratory levels and self-reports) and hypotheses regarding embodiment of early violence victimization as a cause of premature ovarian aging. The stigmatisation of lepers was not a public health measure to control spread but an expression of fear, ignorance and prejudice. Common examples include eczema, psoriasis, acne, rosacea and vitiligo. A study looked at patients with chronic acne, severe enough to merit treatment with isotretinoin. Psoriatic nail disease occurs in about 50 of patients with psoriasis.
Data on national health and epidemiology are often collected using complex probability sample designs involving stratification and clustering of units. Several researchers in the Department of Biostatistics are contributing to this growth, with important innovations in automated image analysis, in the analysis of ordinal and rank data, and in core statistical methodologies like statistical computing and model assessment. Brain Imaging Recent advances in medical imaging technology allow the measurement of brain activity of the intact, living human brain. Specific studies seek to identify genes that play a role in human diseases such as diabetes, asthma, psoriasis, cancer, bipolar disorder, macular degeneration, that allow discrimination of different disease or tumor subtypes, and that explore human genetic variation. A case-control study in 210 psoriasis outpatients and 111 controls with skin diseases other than psoriasis was performed. The exact etiology of psoriasis is not entirely elucidated; there is strong evidence that the interaction of multiple genetic, immunologic, and environmental factors contribute to its pathogenesis. Accordingly, the inflammation that drives psoriatic pathology is systemic 1; this concept carries important public-health implications and has prompted a growing body of research. All studies included a clinical outcome measure and 11 included patient-reported outcomes, however only two studies reported information on patient utilities and two on costs. Prevalence of the disease is around 2-3 of the world population. (psoriasis and psoriatic arthritis) with study types (cohort, epidemiologic, follow-up, longitudinal, prospective, registries, Phase IV, observational).
Clinical Research and Epidemiology: Furthering the understanding of disease and innovating the treatments of tomorrow. M.D., trained in advanced lasers, lead trials in a variety of laser and cosmetic therapies and ensure that research is ongoing within the department in all areas of procedural dermatology. The Henry Ford Hospital Department of Dermatology serves a diverse population. This broad and growing research area encompasses many aspects of epidemiology and public health research including questionnaire design and administration, quality of life measurement, health care access & utilization, and health policy. The Psoriasis Disability Index (PDI) is a widely used instrument to measure the impact of psoriasis on patients. A 2004 study showed that about half of all deaths in the United States in 2000 were due to preventable behaviors and exposures. Scientific advancements in genetics have significantly contributed to the knowledge of hereditary diseases and have facilitated great progress in specific protective measures in individuals who are carriers of a disease gene or have an increased predisposition to a specific disease. These behaviors are modifiable and public health and prevention efforts could make a difference to reduce these deaths. Dr. Hwang will test whether this technique can be used to measure improvements in itch following treatment. This research could lead to the development of new therapies that target these cells. They will use an advanced research technique to study human metabolism to further understand how fatty acids can change skin and blood. Williams will conduct epidemiological studies of psoriasis and its associated health risks by analyzing large patient populations. Here we use MZ twins discordant for psoriasis to search for disease-causing epigenetic and transcriptomic alterations in isolated lymphocyte subpopulations. In addition, several of these genes had previously been identified in GWAS and linkage studies of psoriasis. Affiliation: Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.