Efficacy and Safety of Tazarotene Gel in Nail Psoriasis. This study has been completed. Sponsor: Almirall, S.A. Information provided by (Responsible Party): Almirall, S.A. ClinicalTrials.gov Identifier: NCT02235480. Given the well-documented efficacy of tazarotene on hyperkeratotic nail psoriasis, we investigated its therapeutic use in onychomycosis. Fifteen patients were treated with topical tazarotene 0.1 gel once per day for 12 weeks. The efficacy and safety of tazarotene must be confirmed on a larger number of patients, although already documented in nail psoriasis patients often affected by onychomycosis. A Phase II Trial to Evaluate the Anti-psoriatic Efficacy and Tolerability of Tazarotene in a Gel Formulation in Patients With Mild to Moderate Nail Psoriasis – Parallel Group Comparison. Overview The aim of this study is to determine the efficacy and safety of topical application of the gel compared to placebo in nail psoriasis.
Nail psoriasis results from psoriatic involvement of the nail bed or nail matrix. Tazarotene 0.1 gel or cream is usually applied once daily to the nail plate and periungual skin. Efficacy and safety of ustekinumab in Japanese patients with moderate-to-severe plaque-type psoriasis: long-term results from a phase 2/3 clinical trial. In these studies, tazarotene 0.1 gel, ointment, or cream was used once daily for 1224 weeks. The most recent study investigating tazarotene in nail psoriasis compared the efficacy of pulsed dye laser (PDL) plus topical tazarotene cream versus topical tazarotene alone 57. In a 12-week randomized, controlled, open-label study, the efficacy and safety of topical treatment with tacrolimus 0. We performed an open observational study of 6 patients diagnosed with nail psoriasis. We analyze the efficacy and safety profile of tazarotene 0.1 hydrophilic ointment used to treat nail psoriasis.
Treatment results for nail psoriasis are almost always unsatisfactory and until now there is no standardized treatment regimen. View at Google Scholar; E. S. Tan, W. S. Chong, and H. L. Tey, Nail psoriasis: a review, American Journal of Clinical Dermatology, vol. Studies using tazarotene gel 0.1 have been conducted with successful results in nail psoriasis 25, 27.
Studies using tazarotene gel 0.1 have been conducted with successful results in nail psoriasis 25, 27. Psoriasis localized to certain areas of the body like scalp, nails, palms and soles remains difficult to treat. These sites have been referred to as the difficult locations in literature. Use of potent steroids (twice a day) should be limited to 4 weeks as safety of use beyond 4 weeks is not established. The choice of preparation such as ointment, cream, gel, lotion, foam, spray or shampoo is mostly patient driven. Once-weekly fluconazole (450 mg) for 4, 6, or 9 months of treatment for distal subungual onychomycosis of the toenail. The safety and efficacy of tazarotene gel, a topical acetylenic retinoid, in the treatment of psoriasis. A helpful clue is the presence of psoriatic nail changes: pitting of the nails and separation of the nail from the underlying nail bed. Of 141 patients with nail psoriasis, complete resolution was observed in 63 patients (44.7). A topical form of vitamin D3, calcipotriene (Dovonex) is proving to be both safe and effective.
Safety And Efficacy Of Tazarotene Health And Social Care Essay
Psoriasis localized to certain areas of the body like scalp, nails, palms and soles remains difficult to treat. Colaco et al. demonstrated that occlusion with a hydrogel patch for 8 weeks is safe and efficacious with topical corticosteroids, tacrolimus and combination corticosteroid/calcipotriene.