Keywords: Dapsone, Dermatology, Erythematous plaques, Genital psoriasis, Inverse psoriasis, Skin disease. Local conditions of intertriginous areas, such as warmth, moisture, and friction, make it susceptible to maceration, fissuring, constant irritation, and absence of scaling, which induces the modified clinical appearance of psoriasis in flexion folds when compared with classical characteristics of psoriasis vulgaris. The evidence-based recommendations suggest the use of weaker topical corticosteroids as a first-line treatment, and vitamin D preparations or tar-based treatments as second-line options 1. Circinate pustular psoriasis localized to glans penis mimicking circinate balanitis and responsive to dapsone. Underlying skin disease – eg, psoriasis, dermatitis. Chronic erythematous oral candidiasis (denture stomatitis or chronic atrophic oral candidiasis):Redness of the denture-bearing area – rarely, also soreness. Treat for 14-21 days; the following treatment options are suggested:First-line treatment options:Oral fluconazole (200-400 mg daily). Red, moist skin area with a ragged, peeling edge and possibly pustules or papules at the margin. These detect components of the fungal cell wall or antibodies directed against these antigens (eg, mannan or anti-mannan). Diffuse cerebritis with microabscesses. Specific subjects such as anaerobic infection, Zoon’s balanitis were sought separately and subgroups combined. Symptoms are of burning and itching of the penis with generalized erythema of the glans and/or prepuce which may have a dry glazed appearance, with eroded white papules and white discharge. These changes are similar to those of pustular psoriasis. It has been suggested that these are often due to irritation, particularly if symptoms are persistent or recurrent.
A higher prevalence of benign migratory glossitis (BMG) and fissured tongue (FT) in psoriatic patients compared to the general population has also been cited in many studies 5,8,25,26, prompting some clinicians to consider these oral findings as oral psoriasis’ 4,8,11. The identical histopathological features between BMG, erythema circinata migrans and cutaneous pustular psoriasis provide support for the notion that these oral changes represent oral psoriasis 4,10,18. Moreover, the resolution of both BMG and cutaneous lesions with antipsoriatic agents appears to suggest a common etiology 29. Manifestation of oral psoriasis as diffuse erythema with granular texture confined to the denture-bearing mucosa has been reported 3,14. Erythroderma with pustules. More extensive lesions are sometimes difficult to distinguish from the balanitis of Reiter’s disease. Eating may be complicated by cheilitis and stomatitis, and micturition may be difficult because of balanitis and vulvitis.
An HLA disease association is defined as a statistically increased frequency of the HLA haplotype in individuals with the disease compared to the frequency in individuals without the disease. GU tract – Meatal edema and erythema and clear mucoid discharge; prostatitis; vulvovaginitis; circinate balanitis (balanitis circinata); cervicitis; cystitis; salpingo-oophoritis; pyelonephritis; bartholinitis. Some authors, interpreting the mucocutaneous findings as pustular psoriasis and the seronegative arthritis as psoriatic arthritis, believe that ReA is best classified as a type of psoriasis. This suggests that persistent infection may play a role, at least in some cases of chlamydial-associated ReA. This association points out the likely importance of CD8+ cytotoxic T cells as compared with CD4+ Th cells in the pathogenesis of ReA. Since the initial inflammation in lichen sclerosus affects the basement membrane, it has been suggested that the target antigen must be in this region. It is characterized by the presence of pruritus, diffuse erythematous lesions, epithelial disruption, and lichenifcation.83 Diagnosis may be complicated by the maceration of the area and by lesions caused by scratching. Several clinical forms of the disease can affect the vulva (the flexural and pustular forms as well as psoriasis vulgaris), and vulvar involvement is usually accompanied by lesions in other areas.
Oral Psoriasis: An Overlooked Enigma
The skin manifestations of reactive arthritis are clinically and histologically similar to those of pustular psoriasis.