Development characterization and skin permeating potential of lipid based novel delivery system for topical treatment of psoriasis. Pradhan M1, Singh D1, Singh MR2. 015Feb. Development characterization and skin permeating potential of lipid based novel delivery system for topical treatment of psoriasis. Chem. Phys. Lipids. The aim of the current study was to develop and optimize Fluocinolone acetonide (FA) loaded nanostructured lipid carriers (NLC) and to evaluate its potential as topical delivery system for management of psoriasis. Thus FA loaded NLCs could be a potential system for psoriasis treatment but to create clinical value of the present system further studies are needed in clinically relevant models. Development characterization and skin permeating potential of lipid based novel delivery system for topical treatment of psoriasis.
The novel drug delivery systems aim to fulfill two prerequisites; that is, it delivers the drug at a rate directed by the needs of the body, over the period of treatment, and it carries the drug directly to the inflamed tissues and/or organ. The biologic origin of lipid based vesicles was first reported by Bingham in 1965 and hence was named as Bingham Bodies. Because of the fact that liposomes and niosomes have poor skin permeability, their permeable nature, and their aggregation and fusion in skin tissues, they are not suitable for transdermal delivery of drugs and hence lead to the development of new type of carriers called transfersomes in 1991 by Gregor Cevc. Design, characterization and skin permeating potential of Fluocinolone acetonide loaded nanostructured lipid carriers for topical treatment of psoriasis. Development characterization and skin permeating potential of lipid based novel delivery system for topical treatment of psoriasis. Chime SA, Onyishi VI (2013) Lipid-based drug delivery systems (LDDS): Recent advances and applications of lipids in drug delivery. S (2008) Skin permeation mechanism of aceclofenac using novel nanoemulsion formulation. Agrawal Y, Petkar KC, Sawant KK (2010) Development, evaluation and clinical studies of acitretin loaded nanostructured lipid carriers for topical treatment of psoriasis.
Keywords: Drug, enhanced, permeation, skin, topical, vesicles. Treatment of psoriasis includes topical therapy, systemic therapy and phototherapy. This review highlights the potential of drug-loaded nanoemulsions for the treatment of psoriasis towards achieving better efficacy and eliminating side effects. Nanoemulsions: novel colloidal drug delivery system for psoriasis. Novel drug delivery systems in topical treatment of psoriasis: Rigors and vigors Om Prakash Katare1, Kaisar Raza1, Bhupinder Singh1, Sunil Dogra2 1 Drug Delivery Research Group, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India2 Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education & Research, Chandigarh 160 012, India Date of Web Publication12-Nov-2010. (2004) developed TAM liposomes of multilamellar nature, which exhibited appreciably enhanced skin permeation as well as retention of drug molecules in the skin. Fang et al. developed nanoparticulate lipid-based drug carriers viz.
Lipid Based Vesicular Drug Delivery Systems
Dogra S. Novel drug delivery systems in topical treatment of psoriasis: rigors and vigors. In vitro drug release and human skin permeation studies were performed and analyzed using HPLC. Zeta potential was negative and higher for formulations containing sodium cholate. The IE was much higher for vitamin E- than caffeine-loaded UDV as expected. Keywords: lipid vesicles, topical delivery studies, vitamin E, caffeine. Critical issues related to transfersomes novel vesicular system. The skin permeation and penetration of these elastic vesicles result from a synergic mechanism between the carrier properties and the permeation enhancement ability. Nanostructured lipid carriers: Promising drug delivery systems for future clinics. Factors influencing hydrocortisone permeation into human hair follicles: use of the skin sandwich system. R.M. et al, A novel strategy for the treatment of chronic wounds based on the topical administration of rhEGF-loaded lipid nanoparticles: in vitro bioactivity and in vivo effectiveness in healing-impaired db/db mice. S. A new topical formulation for psoriasis: development of methotrexate-loaded nanostructured lipid carriers.