Skip to content

Data are limited on the use of systemic retinoids for localized pustular psoriasis

Numerous topical and systemic therapies are available for the treatment of the cutaneous manifestations of psoriasis 1

Data are limited on the use of systemic retinoids for localized pustular psoriasis. The data are extremely limited for this type of psoriasis and we encourage further exploration. It can comprise genital skin folds as part of genital psoriasis, and it is one of the most commonly seen dermatoses of this area. Another condition rarely seen is genital compromise with pustular psoriasis as part of a localized or generalized pustular process, but this complication has only been reported in men 1, 9, 30, 31. So far, there are few evidence-based studies regarding the treatment of inverse psoriasis involving genital flexion folds, and data related to efficacy and safety are extremely limited and only supported by expert opinion (level of evidence 5 and recommendation class D) 1.

Numerous topical and systemic therapies are available for the treatment of the cutaneous manifestations of psoriasis 2Pustular psoriasis may be localized or generalized. Even with the use of systemic therapies, additional topical applications are frequently used during disease exacerbations or at therapy resistant sites. Most reports include only small numbers of patients with limited follow-up data. Here in, because of the lack of data in this specific field of dermatology, we decided to review the current therapies of childhood psoriasis. Pustular psoriasis in children has often a better clinical progression than adults considered as a life-threatening disease. Topical retinoid Tazarotene has been recently licensed for use in adults, but there are no data on the efficacy and safety in children. Palmoplantar psoriasis (PPP) is a localized form of psoriasis and can manifest in many different morphologic patterns, from predominantly pustular lesions to thickened, hyperkeratotic plaques and anything in between. Palmoplantar psoriasis (PPP) is a localized form of psoriasis and can manifest in many different morphologic patterns, from predominantly pustular lesions to thickened, hyperkeratotic plaques and anything in between. This review aims to explore the available data on treatment of palmoplantar psoriasis and its unique challenges. Palm and sole disease frequently requires the use of systemic therapies such as retinoids, cyclosporine and methotrexate.

Data are limited on the use of systemic retinoids for localized pustular psoriasis. However, these drugs appear to be particularly effective in the treatment of pustular psoriasis, and we consider them first line therapy. This review focuses on the use of systemic treatments in pediatric psoriasis and their specific features, analyzing the few literature evidences available, expanding the treatment repertoire and guiding dermatologists in better managing of recalcitrant pediatric psoriasis. Both available systemic therapies for pediatric psoriasis and randomized controlled trials supporting their use are limited, so that physicians have to rely on data from case reports and case series from the field of dermatology as well as from the application of the same drugs but for rheumatologic or gastroenterological pediatric conditions. Oral retinoids are safe in children, as verified by long-term follow-up of patients with keratinization diseases, but always require monitoring 32. For patients with limited psoriasis involvement, clinicians can start with topical corticosteroids.

Treatment Of Severe Psoriasis With Infliximab

Pustular and erythrodermic psoriasis may settle with bland topical treatment and hospitalized supportive care unless very severe. However, because of rarity of severe forms of disease in this age group, there is relatively less information with no guidelines or consensus on the use of systemic therapies in childhood psoriasis and it is used mostly empirically. The major limitation of oral retinoids (acitretin) in children is the risk of growth retardation due to premature closure of epiphyses on long-term use. HydroxyureaThere has been a renewed interest on the use of hydroxyurea in Indian patients with psoriasis; 54, 55 however, experience regarding its use in the treatment of childhood psoriasis is limited. The localized form of pustular psoriasis consists of pustules on the palms and soles, without plaque formation (Figure 4). (Tabloid).22 Data do not support the use of systemic corticosteroids in patients with psoriasis. Acitretin is an oral retinoid with a slow onset of approximately three to six months. It was well tolerated in clinical trials, but data on long-term effectiveness and safety are limited.19. This paper will review the data on CsA regimens for plaque-type psoriasis and will focus the attention on dose, treatment duration, novel schedules, and role in combination therapies, including the association with biologicals. The management of a chronic disease like psoriasis is complex and is conditioned by multiple factors, including, but not limited to, the objective severity and distribution of skin lesions, the influence on psychosocial aspects, the response to previous therapies, and the presence of concomitant psoriatic arthritis (PsA) and comorbidities. When psoriasis requires systemic therapy, cyclosporine (CsA) is one of the most effective and rapidly acting drugs. Less severe form presents with multiple localized pustules primarily on palms and soles with painful fissuring. Psoriatic arthritis; not cutaneous psoriasis due to lack of efficacy data in clinical trials (PASI-75 achieved in only 40 of patients after 14 wks—looked at as a secondary outcome of psoriatic arthritis clinical trials). Limited plaque psoriasis (mild-moderate) responds well to what. Difficult to treat; systemic retinoids are first line; may also use topical potent steroids or topical PUVA. IMPORTANCE Generalized pustular psoriasis von Zumbusch type (GPP) is the most severe manifestation of psoriasis. This response was independent of IL36RN mutations and consolidated by combination with low doses of the retinoid acitretin. Pustular psoriasislocalized and generalized (Figure 152-9).

Psoriasis