Many in vitro and in vivo studies demonstrate dose-dependent effects of vitamin D analogs on cell proliferation and differentiation. It is a fact that patients with psoriasis may need intermittent treatment for their whole lives. It is now acepted that vitamin D analogs are effective and safe for the topical treatment of skin areas that are usually difficult to treat and that respond slowly. Michael F. Holick (born 1946) is an American endocrinologist, specializing in the field of vitamin D, such as the identification of both calcidiol, the major circulating form of vitamin D, and calcitriol, the active form of vitamin D. Holick made discoveries in the field of vitamin D that have led to novel therapies for metabolic bone diseases, hypocalcemic disorders, and psoriasis. D3 and several of its analogs were safe and effective for the treatment of psoriasis. Topical Management of Psoriasis and the Role of Vitamin D3 Analogues. From a pharmacologic perspective, factors that can influence treatment decisions include safety and efficacy, onset of action, product characteristics, and cost., erythema, pruritus and skin discomfort) were mild.10 Calcitriol is less irritating than other vitamin D analogues, making it more suitable for use on the face and flexural areas.
Long-term effectiveness and safety of topical calcipotriene for psoriasis. D3 (Durakovic et al., 2001), have been shown to be effective for treating psoriasis. Tacalcitol 4 g/g as a once-daily principle is effective in psoriasis. 3 g/g in petrolatum proved to be safe, with-.
Most treatments for psoriasis are associated with toxic side effects and there continues to be a need for a safe and effective method for treating this disfiguring disorder (27). Although some favorable responses of high-dose vitamin D for psoriasis have been reported, the amounts were so high as to cause significant toxicity and as a result this therapeutic approach lost favor. Results from our laboratory as well as others suggest that 1,25-(OH)2D3 or one of its analogs may be useful for the treatment of psoriasis. Other vitamin D analogs were clinically approved for the treatment of osteoporosis or secondary hyperparathyroidism. 1,25-dihydroxyvitamin D3 and analogs act in a cell type- and tissu. For several conditions such as secondary hyperparathyroidism, psoriasis and osteoporosis, vitamin D analogs are frequently used as a treatment option. These compounds are further evaluated in rodent models to assess their anti-cancer activity and safety in vivo. A number of different approaches are used in the treatment of psoriasis skin plaques. Ergocalciferol or cholecalciferol is effective for treating vitamin D deficiency rickets. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven.
Mild To Moderate Psoriasis, Third Edition
Nongenomic effects of 1,25(OH)2D3 and its analogs are related to effects on intracellular calcium (5,6). In vitro studies revealed that 1,25(OH)2D3 is extremely effective in inducing terminal differentiation and inhibiting the proliferation of cultured human keratinocytes in a dose-dependent manner (14 16). Additionally, 1,25(OH)2D3 acts on many cell types involved in immunologic reactions, including lymphocytes, macrophages, and Langerhans cells (17,18). Because psoriasis is a chronic condition, patients have to cope not only with their disease, but also with their treatments, for prolonged periods of time. Several studies found that topical use of calcitriol (3 g/g) ointment is safe and may be an effective treatment for plaque-type psoriasis (6-8). The active form of vitamin D and its analogs have been shown to upregulate cathelicidin expression in cultured keratinocytes (41, 45). Sunlight regulates the cutaneous production of vitamin D3 by causing its photodegradation.