The overall evaluation of our data gave a roughly equal improvement of plaque psoriasis with both types of treatment. Conclusions A new drug for topical treatment of plaque psoriasis vulgaris is now available: tacalcitol ointment. About 80 of patients with psoriasis are treated topically (Peeters et al 2005). Topical treatment with vitamin D analogs and corticosteroids is the mainstay of first-line therapy for patients with localized psoriasis. The potency of a corticosteroid-containing medication can be influenced by the vehicle in which the corticosteroid is formulated. HPA axis suppression was seen in 20 of adult patients with psoriasis vulgaris treated with high-potency clobetasol ointment.25. Analogs available for the topical treatment of plaque psoriasis in the United States include calcitriol and calcipotriene (calcipotriol). Conclusion.
Numerous topical and systemic therapies are available for the treatment of the cutaneous manifestations of psoriasis. Support for the use of these agents is evident in a systematic review of randomized trials that found that very potent or potent topical corticosteroids are more effective treatments for scalp psoriasis than topical vitamin D analogs 11. Topical calcitriol ointment has been prescribed in Europe for years, and is now available in the United States. Topical synthetic vitamin D analogues used in the treatment of psoriasis include calcipotriol, calcitriol (the active form of vitamin D), maxacalcitol and tacalcitol. In a study on 253 patients with chron- ic plaque type psoriasis, topical calcitriol (3 pg/g) oint- ment had no clinically significant effect on mean serum levels of total calcium, albumin-adjusted total calcium, phosphorus, creatinine, or plasma calcitriol levels. Previously available in ointment, cream and solution, the ointment formulation was withdrawn in the United States by the manufacturer. Get Started Now Deposit & Manage Your Content. The number of daily applications and the cost of drug are important factors affecting the acceptability of treatments. After obtaining informed consent, 34 patients with psoriasis vulgaris treated at our department were enrolled in this study.
Chronic plaque psoriasis (PP) is the most common clinical presentation. Long term efficacy and safety of tacalcitol ointment in patients with chronic plaque psoriasis. Rusanda Spa on plaque psoriasis in patients also treated with calcipotriol.
Treatment Of Psoriasis
There are a number of systemic treatments for psoriasis and psoriatic arthritis which have been examined in numerous randomised controlled trials (RCTs) 18, 19. The National Institute of Clinical Excellence stresses that decision-makers need to assess and appraise all the available evidence regardless of whether it has been derived from a RCT or an observational study. Although there are now guidelines on the reporting of observational studies (Strengthening the Reporting of Observational Epidemiological studies – STROBE) 25 which guide the author how to present their data, there are no consensus guidelines on quality assessment of such studies. Plaque psoriasis (chronic). Lecha 200570, Spanish tacalcitol ointment study. In addition, before starting a new technique or engaging a practitioner, it is recommended that patients speak with their primary healthcare provider(s). Vitamin D3 (tacalcitol) ointment has been reported as being safe and well tolerated. Ergocalciferol or cholecalciferol is effective for treating vitamin D deficiency rickets. It is widely used for the treatment of plaque psoriasis.