These results show that the combination of topical MC 903 and UVB radiation is well tolerated. Larger-scale studies are. Combination Regimens of Topical Calcipotriene in Chronic Plaque Psoriasis: Systematic Review of Efficacy and Tolerability. Kragballe K Combination of topical calcipotriol (MC903) and UVB radiation for psoriasis vulgaris. Both ultraviolet (UV) B phototherapy and topical calcipotriol are established treatment modalities for psoriasis.
Hecker D, Lebwohl M. Topical calcipotriene in combination with UVB phototherapy for psoriasis. Int J Dermatol 1997;36: 302-3. 34. Kragballe K. Combination of topical calcipotriol (MC903) and UVB radiation for psoriasis vulgaris. In spite of the well established role of topical vitamin D analogs in psoriasis, the precise mechanisms underlying their therapeutic effectiveness are still not completely understood. Kragballe K. Combination of topical calcipotriol (MC 903) and UVB radiation for psoriasis vulgaris.
This review summarizes laboratory and clinical investigations related to the treatment of psoriasis with calcitriol or analogs. 10 of patients treated with calcipotriol (50 g/g) and was not reported after topical treatment with calcitriol. Kragballe K. Combination of topical calcipotriol (MC 903) and UVB radiation for psoriasis vulgaris. The combination of topical treatment with vitamin D analogs and UV-radiation does not alter the tolerability or safety of therapy.7272. Efficacy and safety of combinations of first-line topical treatments in chronic plaque psoriasis: a systematic literature review. Comparison of calcipotriol monotherapy and a combination of calcipotriol and betamethasone valerate after 2 weeks’ treatment with calcipotriol in the topical therapy of psoriasis vulgaris: a multicentre, double-blind, randomized study. Comparative effects of calcipotriol (MC903) solution and placebo (vehicle of MC903) in the treatment of psoriasis of the scalp. 5,6 In another study, patients whoreceived topical applications of calcipotriol ointment twice daily and NB-UVB phototherapy more than twice a week showed marked and rapid reduction in PASI scores.