In rheumatoid arthritis (RA), early diagnosis and early initiation of aggressive therapy has become a primary objective for clinical rheumatology1. Clinical and genetic aspects of psoriatic arthritis sine psoriasis. PubMed journal article Clinical presentation of psoriatic arthriti was found in Unbound MEDLINE. Clinical and genetic aspects of psoriatic arthritis sine psoriasis. Dactylitis is clinically diagnosed and is an important indicator of PsA. Clinical and genetic aspects of psoriatic arthritis sine psoriasis.
Clinical and genetic aspects of psoriatic arthritis sine psoriasis. Psoriatic arthritis: overview and guidelines of care for treatment with an emphasis on the biologics. F. et al, Clinical and genetic aspects of psoriatic arthritis sine psoriasis. Because the clinical presentation can be varied, five different subtypes of PsA have been described and can overlap (Box 1). There appear to be multiple factors contributing to the pathogenesis of PsA, including genetic, environmental, and immunologic.
The clinical spectrum of PsA sine psoriasis is wide and identified by dactylitis and/or distal interphalangeal arthritis, HLA-Cw6, and a family history of psoriasis. The ClASiffication of Psoriatic ARthritis (CASPAR) criteria of PsA include PsA sine psoriasis. Patients with genetic dysfunctions of the innate immune system causing autoinflammatory syndromes show an exaggerated release of mature IL-1 upon stimulation with LPS alone. PCA3 in prostate cancer5,6 and to reveal uncharacterized aspects of tumor biology. METHODS: Five hundred and two patients, affected by plaque psoriasis, PsA ‘sine psoriasis’ or a combination of psoriasis and PsA and with a diagnosis of at least one AD, were retrospectively evaluated. CONCLUSION: The new concept of psoriatic disease, focusing on genetic and molecular aspects which are at the basis of the pathogenesis of psoriasis and its related manifestations, extended the traditional idea of a disease confined to skin and joints. In this context, the multidisciplinary assessment of patients in the combined Dermatology/Rheumatology outpatient clinics would allow to identify early clinical and laboratory abnormalities not limited to skin and joint. Helliwell PS (2009) Established psoriatic arthritis: clinical aspects. J.
Relationship of psoriatic arthritis with the other spondyloarthropathies. PSORIATIC ARTHRITIS AND PSORIASIS, Autor:Adebajo, ISBN: 9783319195292,Temtica: GERIATRIA. PATHOLOGY AND CLINICAL ASPECTS. Adebajo.