Effectiveness of chondroitin sulphate in patients with concomitant knee osteoarthritis and psoriasis: a randomized, double-blind, placebo-controlled study. (CS) on symptomatic knee osteoarthritis (OA) associated to psoriasis. Efficacy and Safety of a New Formulation of Chondroitin Sulfate and Glucosamine Sulfate to Treat Knee Osteoarthritis. Purpose The main objective is to assess the efficacy of a new formulation containing chondroitin sulfate and glucosamine sulfate (CS+GS) compared with placebo in patients with primary osteoarthritis of the knee. Concurrent arthritic disease (antecedents and/or current signs) that could confound or interfere with the evaluation of pain efficacy such as chondrocalcinosis, Paget’s disease of the ipsilateral limb to the target knee, rheumatoid arthritis, aseptic osteonecrosis, gout, septic arthritis, ochronosis, acromegaly, haemochromatosis, Wilson’s disease, osteochondromatosis, seronegative spondyloarthropathy, mixed connective tissue disease, collagen vascular disease, psoriasis, inflammatory bowel disease or fibromyalgia.
The effect of chondroitin sulfate in patients with osteoarthritis is likely the result of a number of reactions including its anti-inflammatory activity, the stimulation of the synthesis of proteoglycans and hyaluronic acid, and the decrease in catabolic activity of chondrocytes inhibiting the synthesis of proteolytic enzymes, nitric oxide, and other substances that contribute to damage cartilage matrix and cause death of articular chondrocytes. These results suggest that chondroitin sulfate may improve osteoarthritis knee pain in patients with relatively early radiographic disease. Effectiveness of chondroitin sulphate in patients with concomitant knee osteoarthritis and psoriasis: a randomized, double-blind, placebo-controlled study. Study on Efficacy and Safety of Chondroitin Sulfate + Glucosamine Hydrochloride Versus Celecoxib in Knee Osteoarthritis (MOVES). In Combination Versus Celecoxib In Patients With Knee Osteoarthritis Resource links provided by NLM:. Bucsi L, Poor G. Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis. Effectiveness of chondroitin sulphate in patients with concomitant knee osteoarthritis and psoriasis: a randomized, double-blind, placebo-controlled study. Krejci G. Efficacy and safety of piascledine 300 versus chondroitin sulfate in a 6 months treatment plus 2 months observation in patients with osteoarthritis of the knee.
Most often, OA develops in the hands, knees, hips, and spine. Although balneotherapy is most often used for psoriatic or rheumatoid arthritis, some medical experts believe that it may help people with OA as well. Treatment options in knee osteoarthritis: the patient’s perspective. Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Benefits of antioxidant supplements for knee osteoarthritis: rationale and reality. The clinician diagnoses it as OA by ruling out other causes such as rheumatoid, psoriatic and septic arthritis, injury and other causes. There are a large number of treatments of varying efficacy and faith for OA. However, the combination of glucosamine and chondroitin sulfate is the most promising.
Chondroitin sulfate is considered a promising treatment for osteoarthritis. It is most often used to treat osteoarthritis of the finger, knee, hip joints, low back, and facial joints. However, adequate assessment of long-term safety, side effects, and effectiveness is lacking. Studies suggest that chondroitin sulfate may improve symptoms of psoriasis, a condition causing skin redness and irritation. ArthritisImaging in RheumatologyLupusOsteoarthritisOsteoporosisPsoriatic ArthritisGeriatricsGout. Chondroitin Sulfate Use Linked to Reduced Need for Knee Replacement. Self-help options exemplify the first, do no harm principle, and several have been shown to have significant efficacy in patients with knee OA. Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT. Patient Care & Health InfoHealthy Lifestyle. Safety and effectiveness have not always been proven. Knee osteoarthritis appears to respond better than other joints to any treatment. Early study suggests that a product containing both glucosamine sulfate and chondroitin sulfate may benefit interstitial cystitis symptoms. Keywords: chondroitin, clinical trials, Knee, osteoarthritis and pain. Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): Treatment Recommendations for Psoriatic Arthritis 2015. Chondroitin sulfate is effective for the treatment of knee osteoarthritis 1. Controlled clinical trials in patients with osteoarthritis show good efficacy of chondroitin sulfate, improving the symptomatology and the functional variables significantly compared to placebo 6, 7, 8. The efficacy of combined chondroitin sulphate plus glucosamine for knee osteoarthritis (OA) is debated, but the suggestion, from analysis of past clinical trials, that a subgroup of patients with moderate to severe pain might benefit from this therapy has now been further explored in the phase IV MOVES (Multicentre Osteoarthritis. Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: a multicentre, randomised, double-blind, non-inferiority trial versus celecoxib. Risk factors Cardiovascular risk in patients with psoriatic arthritis.
Chondroitin sulfate reduced long-term progression of structural changes in patients with knee osteoarthritis. SYSADOAs are of interest because of their good safety profile, efficacy on symptoms, and protective effect on disease progression. Chondroitin sulfate supplement and glcusoamine for arthritis treatment, 400 mg tablets, for osteoarthritis treatment, benefit and side effects, by Ray Sahelian, M. Diabetes and blood sugar One study providing a combination of glucosamine and chondroitin for a period of 90 days did not find any change in blood sugar levels so it appears to be safe for diabetics. We describe the clinical and histopathological results of plaque psoriasis in eleven adult patients with knee osteoarthritis and long-standing, moderate to severe psoriasis resistant to conventional therapy treated with chondroitin sulfate. This study confirms the partial efficacy of oral chondroitin sulfate in improving some aspects of osteoarthritis. The safety of the drug was good in clinical trials and in the postmarketing surveillance. (2009) Glucosamine therapy for knee osteoarthritis: pharmacokinetic considerations. The supplements are safe to try, but benefits may be modest. Chondroitin sulfate and glucosamine are popular supplements used to treat the pain and loss of function associated with osteoarthritis (OA). However, most studies assessing their effectiveness show modest to no improvement compared with placebo in either pain relief or joint damage. Glucosamine may provide modest pain relief for some patients with osteoarthritis of the knee, hip and spine.
Care, however, must be taken for patients on anticoagulants where these supplements (but not MSM) may interact and cause bleeding problems, so they are contraindicated in those patients. Most research on glucosamine sulfate has measured its effectiveness on osteoarthritis of the knee. Some researchers hope that glucosamine sulfate might keep osteoarthritis from getting worse as quickly as it otherwise might. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Treatments for Psoriatic Arthritis: An overview A positive approach to psoriasis and psoriatic arthritis What are the aims of this leaflet? This leaflet has been written to help you understand the treatments. Glucosamine and chondroitin sulfate are used to treat osteoarthritis. The multicenter, double-blind, placebo- and celecoxib-controlled Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) evaluated their efficacy and safety as a treatment for knee pain from osteoarthritis. Exploratory analyses suggest that the combination of glucosamine and chondroitin sulfate may be effective in the subgroup of patients with moderate-to-severe knee pain. (2010) Effectiveness of chondroitin sulphate in patients with concomitant knee osteoarthritis and psoriasis: a randomized, double-blind, placebo-controlled study.