Drugs have several ways in which they can affect the diathesis of psoriasis including 1) precipitation of psoriasis de novo in predisposed and nonpredisposed individuals; 2) exacerbation of pre-existing psoriatic lesions; 3) induction of lesions in clinically normal skin in patients with psoriasis; and 4) development of treatment-resistant psoriasis. 53,54 In another group, 42 percent (20/48) of American soldiers with psoriasis given chloroquine for the prophylaxis of malaria had exacerbation of psoriasis, which was treatment resistant. Some medications make your psoriasis worse, but your doctor may be able to suggest other treatments that can manage your health problems without causing flare-ups. Ask your doctor if you can switch to a medicine that won’t affect your skin condition. If your plans include travel to southern Africa or another malaria-prone part of the world, you might need medicine to protect yourself against this mosquito-borne disease. Learn about psoriasis causes and how you can treat psoriasis. Certain medications are associated with triggering psoriasis, including:. Antimalarials: Plaquenil, Quinacrine, chloroquine and hydroxychloroquine may cause a flare of psoriasis, usually two to three weeks after the drug is taken.
Environmental factors: a number of factors may trigger or exacerbate plaque psoriasis, including:Sunlight: there is usually a decrease in severity during periods of increased sun exposure (ie it often improves in the summer and is worse in the winter) but a small minority has an aggravation of symptoms during strong sunlight and sunburn can also lead to an exacerbation of plaque psoriasis. Antimalarials. The number of lesions may range from few to many at any given time. For very widespread plaque psoriasis, the same treatments may be appropriate but dithranol is often impracticable and more potent corticosteroids hazardous if used on a long-term basis. It may be possible to avoid certain triggers that may worsen or aggravate the condition, but prevention itself is not possible. A cold, dry climate can also worsen symptoms of psoriasis. Some medications interfere with your body’s autoimmune response and can cause a severe psoriasis attack. These include beta-blockers, which are used for high blood pressure, steroidal medicines, and pills taken to stop malaria.
Some of the most common medications know to trigger or worsen existing psoriasis include lithium, gold salts, beta blockers and antimalarials. This inflammation can also affect the joints causing psoriatic arthritis The exact mechanism that stimulates these T cells into their harmful behaviour is not known but a number of trigger factors have been discovered. Both trauma and certain bacteria may also trigger psoriatic arthritis.
Chronic Plaque Psoriasis. Symptoms, Causes And Treatment
Dead skin and white blood cells can’t slough off quickly enough and build up in thick, scaly patches on the skin’s surface. Certain medications including lithium, which is prescribed for bipolar disorder; high blood pressure medications such as beta blockers; antimalarial drugs; and iodides. Considerations when choosing a drug for malaria prophylaxis:.