Lancet. 1991 Aug 3;338(8762):320-1. Chimaeric CD4 monoclonal antibody in treatment of generalised pustular psoriasis. Prinz J, Braun-Falco O, Meurer M, Daddona P, Reiter C, Rieber P, Riethm ller G. Chimaeric CD4 monoclonal antibody treatment of generalised pustular psoriasis on ResearchGate, the professional network for scientists. CD4 monoclonal antibody in treatment of generalized pustular psoriasis.
Psoriatic skin was transplanted onto SCID mice, which were then injected with autologous T cells. Successful treatment for severe psoriasis and generalised pustular psoriasis has been reported with basiliximab, an interleukin-2 receptor (IL-2R; CD25) chimeric monoclonal antibody 18, 19. It is a humanised antihuman CD4 IgG4 monoclonal antibody preventing the recognition of the MHC-bound antigen by an appropriate T-cell receptor, hence T cells do not get activated 39. Infliximab, a chimeric anti-TNF monoclonal antibody administered by intravenous infusion, was the first TNF blocker studied for the treatment of psoriasis. Gaylor ML, Duvic M. Generalized pustular psoriasis following withdrawal of efalizumab.
Pustular psoriasis is an uncommon form of psoriasis consisting of widespread pustules on an erythematous background, as shown in the image below. CD4+ T cells, and macrophages and, when activated, promote maturation of monocyte-derived dermal dendrocytes and inductions of cytokines, including IL-1, IL-6, IL-23, tumor necrosis factor-alpha (TNF-a), and interferon-gamma (INF-g), which promote neutrophil migration. The study of IL35RN gene mutations in the pathogenesis of generalized pustular psoriasis has led to new advances in treatment. Tocilizumab is a monoclonal antibody that blocks IL-6 activity at both soluble and membrane-bound complexes, thus inhibiting IL-6 dependant STAT1/STAT3 activation. Though generalized PP formally belongs to the psoriasis spectrum because of its frequent clinical association with PV and multiple similarities in molecular pathogenesis, it is debated whether it may represent a distinct clinicopathological entity 16, 17. Tocilizumab is a monoclonal antibody which globally blocks IL-6 biologic activity by antagonizing both conventional membrane-bound signaling and sIL-6/IL-6R transsignaling, resulting in a strong inhibition of IL-6-dependent STAT1/STAT3 activation 70. Chimaeric CD4 monoclonal antibody in treatment of generalised pustular psoriasis.
T-lymphocyte Dependence Of Psoriatic Pathology In Human Psoriatic Skin Grafted To Scid Mice
In contrast to pustular types of psoriasis, these patients show genetic susceptibility and strong association with MHC class I and class-I haplotypes. Has severe, unstable, life threatening disease as pustular psoriasis or erythrodermic psoriasis. Efalizumab is a recombinant humanized monoclonal IgG1 antibody that binds to CD11a, the a subunit of leukocyte function-associated antigen 1 (LFA-1).