Abstract. Background: Systemic methoxsalen PUVA increases nonmelanoma skin cancer risk in a dose-dependent manner, whereas trioxsalen bath PUVA treatment has been suggested to be less carcinogenic. Still, the three-fold increased rate of lymphoma translates to only 12 additional cases for every 10,000 people with psoriasis. The skin condition affects about 5 million Americans. British Journal of CancerISSN: 0007-0920EISSN: 1532-1827. Humans Male Neoplasms Psoriasis Scotland Sex Factors Skin Neoplasms.
Patients with psoriasis had a 2.95 relative rate of developing lymphoma (95 confidence interval, 1. These diseases are relatively rare forms of cancer (their incidence rates are similar to those for invasive melanoma), and to detect an increased risk for these diseases a large population of patients needs to be studied. Cancer Incidence in TNF Inhibitor Treated Patients with Axial Spondyloarthritis and Psoriatic Arthritis a Study from the ARTIS and Danbio Registers. Its prevalence in Western populations is estimated to be around 2 3 (Gudjonsson and Elder, 2007). An increased risk of cancer has been predicted among psoriasis patients because of the dysregulated immune function and the potential carcinogenicity of certain therapeutic regimens, such as UV exposure and immunosuppressant drugs (Arellano, 1997; IARC, 2000).
The overall cancer incidence was increased (standardized incidence ratio 1.3, 95 confidence interval 1. It can occur at any age but the majority of cases first present before the age of 35 years. A number of studies have suggested that people with psoriasis may have an increased risk of cardiovascular disease, lymphoma and non-melanoma skin cancer. Patients with mild psoriasis are not associated with higher rates of mortality than the general population and the life expectancy is considered to be equal. In severe cases, the treatments required to control the psoriatic symptoms can have harsh adverse effects and may increase the risk of other health conditions, such as skin cancer, lymphoma and liver disease.
Risk of basal cell cancer was substantially increased only in those patients exposed to very high levels of PUVA ( 337 treatments). Incidence of skin cancer in Japanese psoriatic patients treated with either methoxsalen phototherapy, Goeckerman regimen, or both therapies.