In psoriasis, the immune system triggers the immune system to make T cells, a type of white blood cell, that cause skin cells to mature in two to three days. Plaque psoriasis can develop on any part of the body, but most often occurs on the elbows, knees, scalp, and trunk. There may be a red drop-like rash (guttate psoriasis) or patches of scaly skin that crack and ooze pus (pustular psoriasis). Any sun exposure or UVB treatment should be coordinated with a dermatologist. Autoimmune disorders are caused by dysfunctional immune responses directed against the body’s own tissues, resulting in chronic, multisystem impairments that differ in clinical manifestations, course, and outcome. Systemic sclerosis (scleroderma) constitutes a spectrum of disease in which thickening of the skin is the clinical hallmark. Although arthritis can occur, joint dysfunction results primarily from soft tissue/cutaneous thickening, fibrosis, and contractures. Definition/Description Psoriatic arthritis is a chronic progressive inflammatory joint disease that can be associated with psoriasis. Even though it is associated with psoriasis, in 15 of cases the arthritis appears first. Dactylitis: Occurs in one third of the psoriatic arthritis population that presents as swelling of the whole the finger making them appear sausage-like. Since disease manifestations first begin within the skin and nails, it is likely the patients first point of contact is a dermatologist, putting them in an optimal position to be the first to screen for PsA.
Isocyanate skin exposure can occur at work, even with the use of personal protective equipment, and may also occur with consumer use of certain isocyanate products. In animals, isocyanate skin exposure is an efficient route to induce sensitization, with subsequent inhalation challenge resulting in asthma-like responses. Contact hypersensitivity (allergic contact dermatitis) following skin exposure to isocyanates is well documented in animals and in the clinical dermatologic literature, with sensitization confirmed with patch testing (Goossens et al.
Skin Exposure To Isocyanates: Reasons For Concern