To evaluate the feasibility of Retrovir (AZT) in the treatment of psoriasis in HIV antibody positive patients. Retrovir has been shown to be effective in the treatment of AIDS. In addition, the administration of AZT appears to have induced a remission of psoriasis in one case study. A Study of Retrovir in the Treatment of Psoriasis in HIV-Positive Patients. This study has been completed. Sponsor: Glaxo Wellcome. Information provided by: NIH AIDS Clinical Trials Information Service. ClinicalTrials.gov Identifier:. RETROVIR IV Infusion in combination with other antiretroviral agents is indicated for the treatment of HIV infection. Maternal-Fetal HIV Transmission: RETROVIR is also indicated for the prevention of maternal-fetal HIV transmission as part of a regimen that includes oral RETROVIR beginning between 14 and 34 weeks of gestation, intravenous RETROVIR during labor, and administration of RETROVIR Syrup to the neonate after birth.
5 A Study of Retrovir in the Treatment of Psoriasis in HIV-Positive Patients. The Safety and Effectiveness of Zidovudine (AZT) in the Treatment of HIV Infection in Patients With AIDS and Advanced ARC. Condition: HIV Infections. A Study of Retrovir in the Treatment of Psoriasis in HIV-Positive Patients. Condition: HIV Infections; Psoriasis. Phase I Pilot Study of Gene Therapy for Cystic Fibrosis Using Cationic Liposome Mediated Gene TransferCompletedCystic FibrosisGenetic – pGT-1 gene lipid complexUniversity of Alabama at Birmingham; OtherMale, Female16 Years – N/APhase 1Interventional – Primary Purpose: TreatmentOBJECTIVES: Determine whether copies of the cystic fibrosis gene (pGT-1) can be delivered to the cells lining the nose of cystic fibrosis patients using cationic liposome (DMRIE/DOPE) mediated gene transfer.
First-line therapy for managing psoriasis in HIV-positive patients is treating the HIV infection with HAART therapy. In some cases they may not be available in every strength or form as the brand. There have been a few studies done in humans that did not show an increase in birth defects in babies born to mothers who have taken zidovudine during pregnancy. HIV-Positive Pregnant Women: If you’re pregnant and HIV positive, your doctor may decide to give you a special dose of Retrovir to help prevent passing HIV to your baby. Psoriasis clinical trials, research treatments, cure research, and other treatments.
Zidovudine (Retrovir) has been used occasionally to attenuate the illness, with mixed results. In most patients who are HIV-positive, the diagnosis and treatment of skin infections are relatively straightforward. When psoriasis antedates HIV infection, the skin lesions usually worsen as the immune system weakens. Researchers found that HIV-positive people have less-than-normal levels of GSH in many tissues and fluids such as blood, the lungs and many different types of the immune system’s cells, including CD4+, CD8+, natural killer and monocytes/macrophages. At the time of the study, powerful anti-HIV drugs such as protease inhibitors were not available and most participants used AZT (zidovudine, Retrovir) with or without another nuke (nucleoside analogue). German researchers who have used DMF for treating patients with psoriasis have stated that the drug’s side effects are lessened after the first month of use. Some authors consider the development of psoriasis in seropositive patients as an ominous prognostic sign, but this view is not supported by all studies. Zidovudine may prove the treatment of choice of psoriasis in HlV-seropositive patients, but its use warrants further investigation. A Study of Retrovir in the Prevention of HIV Infection in Health Care Workers Accidentally Exposed to the Virus. Therapy: Zidovudine 14784. A Study of Retrovir in the Treatment of Psoriasis in HIV-Positive Patients. In a small number of cases, this early stage of infection may progress to meningitis (inflammation of membranes covering the brain) or severe flulike symptoms that require hospitalization. Many studies have shown that people with high levels of virus in the blood (the viral load) will progress more rapidly to AIDS. The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. Remission of AIDS-associated psoriasis with zidovudine Letter. Lancet. Zidovudine for the treatment of thrombocytopenia associated with human immunodeficiency virus (HIV) a prospective study.