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A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele

A susceptibility gene for psoriasis, a chronic skin disorder, resides in chromosome 6p near the HLA-C locus. In conclusion, we have studied HCR, a new highly polymorphic gene near HLA-C, which by position, genetic association results and expression pattern in normal and psoriatic skin must be considered a candidate gene for psoriasis susceptibility. Association analysis did not support CD5 as a psoriasis susceptibility allele in their sample. (2001) investigated the HCR gene for disease association by direct sequencing of 9 PCR products amplified from a series of Swedish psoriasis patients and controls. A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele. HGNC approved symbol report for the gene CCHCR1 (HGNC_ID:13930). A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele. Asumalahti K et al. Hum. Mol. Genet.

Drugs used for psoriasis (D05) 2A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele. Hum Mol Genet, 9 (2000), pp. Disease: Variants have been found in patients and disease-association is reported in literature. Polymorphism: HCRWWCC is associated with susceptibility to psoriasis. Variant description: In allele HCRWWCC; associated with psoriasis. A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele. Meta-analysis of genome-wide studies of psoriasis susceptibility reveals linkage to chromosomes 6p21 and 4q28-q31 in Caucasian and Chinese Hans population. U, and Kere, J. A candidate gene for psoriasis near HLA-C, HCR (Pg8) is highly polymorphic with a disease-associated susceptibility allele.

The identification of the disease risk gene within the PSOR1 locus, however, has been difficult, largely due to the fact that several genes show evidence for association with the disease development and the evidences are highly correlated and hard to be separated from each other. Fine Mapping of the Psoriasis Susceptibility Locus PSORS1 Supports HLA-C as the Susceptibility Gene in the Han Chinese Population. Several fine-mapping studies have highlighted a 300-kb candidate region of PSORS1 where multiple biologically plausible candidate genes were suggested. This analysis identified a 16 SNP chromosome conferring significant disease risk both in the UK and the Gujurati data sets. CDSN susceptibility alleles on haplotypes bearing HLA-C related risk SNPs. A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele. Psoriasis susceptibility loci identified before genome-wide association studies. Kere J: A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele. Hum Mol Genet.

The Hcr Gene On 6p21 Is Unlikely To Be A Psoriasis Susceptibility Gene

Drugs used for psoriasis (D05) 3A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele. HCR; SBP; Pg8; C6orf18; Alpha-helical coiled-coil rod protein; Putative gene 8 protein. Europe PMC Abstract; A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele. We have shown that KIR2DS2 is associated with PsA when compared with healthy controls. HLA-C 0602 allele confers the highest risk for psoriasis. Three genes contained within this region are associated with psoriasis, namely HLA-Cw6, CCHCR1 (coiled-coil -helical rod protein) and CDSN (corneodesmosin). This variant has been convincingly identified as the susceptibility allele of the PSORS1 locus 9 11. (2000) A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele. PSORS1 (psoriasis susceptibility gene 1) is a major susceptibility locus for psoriasis. The most recent study has indicated HLA-Cw6 as the primary PSORS1 risk allele within the candidate region in a Caucasian population.

Plos Genetics: Fine Mapping Of The Psoriasis Susceptibility Locus Psors1 Supports Hla-c As The Susceptibility Gene In The Han Chinese Population