Psoriasis is a long-lasting autoimmune disease characterized by patches of abnormal skin. These skin patches are typically red, itchy, and scaly. The odds of having hypertension are 1.58 times higher in people with psoriasis than those without the condition; J Am Acad Dermatol 58 (5): 82650. doi:10.1016/j.jaad.2008.02.039. People with psoriasis are at increased risk of developing other health conditions such as diabetes, heart disease, and depression. People with severe psoriasis are 58 percent more likely to have a major cardiac event and 43 percent more likely to have a stroke, according to one study. There is a significant association between psoriatic disease and metabolic syndrome a cluster of conditions that include heart disease, abdominal obesity and high blood pressure. People with severe psoriasis are twice more likely to develop chronic kidney disease than those who psoriasis was mild or had no psoriasis at all, according to an analysis of more than 140,000 psoriasis patient records in the United Kingdom. Learn about related conditions, including psoriatic arthritis. According to the National Psoriasis Foundation, if you have severe psoriasis, your chance of having a major cardiac event is 58 percent higher than that of people who don’t have psoriasis, and your risk for stroke is 43 percent higher. And that gap further increases for younger people: A 30-year-old person with severe psoriasis carries three times the heart attack risk of a 30-year-old without psoriasis. Research shows that people with severe psoriasis have a 72 percent increased risk for a mood disorder, while those with mild psoriasis have a 38 percent increased risk.
Patches usually appear as smooth inflamed areas without a scaly surface. AIDS patients and those with severe psoriasis are at higher risk for developing PsA. The condition is very similar to, but less disabling than, rheumatoid arthritis. Psoriasis is a chronic inflammatory immune-mediated skin diseases which is frequently associated to comorbidities. Moreover, patients with NAFLD and psoriasis are at higher risk of severe liver fibrosis than those with NAFLD and without psoriasis. McDonald et al 41 have shown that the global risk of arterial and venous diseases appeared to be 2.2 times higher in psoriatic patients compared with control patients affected by different skin diseases 41. 2009;58:727736. Clinical features of PsA, including comorbid conditions and disease activity, contribute to reduced physical and psychosocial health-related quality of life. 1,2 The overall prevalence of PsA in the U.S. ranges from 101 to 250 per 100,000 people, with an annual incidence reported at 6., patients who had PsA for longer than two years had rates of depression that were two to five times higher than those of age-matched controls who had no history of PsA or psoriasis. 58. Frediani B, Allegri A, Falsetti P, et al. Bone mineral density in patients with psoriatic arthritis.
The presence of comorbid conditions in psoriasis patients has important implications for clinical management. The prevalence of streptococcal infection during sore throat was 10 times higher in people with psoriasis than in controls and can exacerbate chronic plaque psoriasis 20. Joint pain (psoriatic arthritis) without any visible skin findings. The differentiation of psoriatic arthritis from rheumatoid arthritis and gout can be facilitated by the absence of the typical laboratory findings of those conditions. Psoriasis causes skin cells to mature in less than a week. The top scales flake off easily and often, but those beneath the surface of the skin clump together. At least 50 of every 100 people who have any form of psoriasis have scalp psoriasis.
Psoriasis and psoriatic arthritis can be associated with other diseases and conditions, including diabetes, cardiovascular disease and depression. Up to 40 percent of people with psoriasis experience joint inflammation that produces symptoms of arthritis. Approximately 80 percent of those affected with psoriasis have mild to moderate disease, while 20 percent have moderate to severe psoriasis affecting more than 5 percent of the body surface area. The incidence of Crohn s disease and ulcerative colitis, two types of inflammatory bowel disease, is 3.8 to 7.5 times greater in psoriasis patients than in the general population.6. Those with a high intake of green vegetables, carrots, tomatoes, and fresh fruits are less likely to develop psoriasis. By the time I turned 50 in 1999, I was covered from head to toe with psoriasis and tested positive for other autoimmune diseases: rheumatoid arthritis, lupus, Hashimoto s and Sjogren s. However, these drugs appear to be particularly effective in the treatment of pustular psoriasis, and we consider them first line therapy. Data are limited on the efficacy of biologic agents other than infliximab for the treatment of erythrodermic psoriasis. Lepers were cast out from society in biblical and medieval times as they were considered ‘unclean’. Those who have skin diseases have not only to cope with the effects of their disease but also the reaction of others to their condition. Common examples include eczema, psoriasis, acne, rosacea and vitiligo. Acne is associated with a greater psychological burden than a variety of other disparate chronic disorders. Psoriatic arthritis is a debilitating condition, which affects approximately one-quarter of psoriasis patients. Patients with PsA who were started on etanercept within two years of disease onset had a more significant improvement in pain assessments than those who had PsA for more than two years prior to commencing etanercept 6. Currently, there is no validated disease activity score for psoriatic arthritis. Participants Cohort study: patients with psoriasis aged 18-90 each matched to up to five patients without psoriasis based on age, practice, and time of visit. Patients were classified as having diabetes, hypertension, hyperlipidemia, and cardiovascular disease if they ever received a diagnostic code for these conditions before the start of the study. Patients with psoriasis were more likely to have diabetes, hypertension, cardiovascular disease, and higher BMI than people without psoriasis, consistent with previous studies.
The Importance Of Disease Associations And Concomitant Therapy For The Long-term Management Of Psoriasis Patients
The majority of people with psoriasis experience adverse physical, psychological, and social effects. Patients with psoriatic arthritis have worse quality of life than those with psoriasis alone. Patients with psoriasis have a higher risk for depression than those without the disorder, independent of cardiovascular comorbidities. In the study of people with psoriasis, an inflammatory skin condition, researchers found that the severity of a person’s psoriasis was linked to the amount of inflammation in the blood vessels, a factor that increases risk of heart disease. In people with psoriasis, skin cells rise from the skin’s lower layers to the surface of the skin too quickly, which doesn’t leave enough time for the old skin cells to fall off, so the dead skin cells build up to form thickened patches on the surface. In the study, the researchers looked at 60 patients with psoriasis and 20 people without psoriasis. Psoriasis patients should also ask their health care providers to screen them for other heart disease risk factors, such as high cholesterol, high blood pressure, obesity and diabetes, he said.