Tacalcitol ointment for the treatment of nail psoriasis. Treatment with tacalcitol ointment may be useful to treat nail psoriasis as it achieves a significant improvement in all nail parameters, both of the matrix and of the bed. Psoriatic nails is a nail disease. It is common in those suffering from psoriasis, with reported incidences varying from 10 to 78. There exist numerous treatments for nail psoriasis but there is little information concerning their effectiveness and safety. As of April 2009, an assessment of the evidence for the efficacy and safety of the treatments for nail psoriasis is in progress. The study started in October 2009 and ended in April 2010. Of the 3 vitamin D derivatives calcipotriol, tacalcitol, and calcitriol, the most widely studied in Spain is calcipotriol, which was effective in the nail bed (not in the matrix) and reduced hyperkeratosis.
Journal of Dermatological Treatment 2009, 20 (5): 308-10. Treatment with tacalcitol ointment may be useful to treat nail psoriasis as it achieves a significant improvement in all nail parameters, both of the matrix and of the bed. View at Google Scholar; D. de Berker, Management of psoriatic nail disease, Seminars in Cutaneous Medicine and Surgery, vol. 3943, 2009. Evaluation of tolerability and efficacy of tacalcitol ointment in moderate psoriasis.
Fifteen patients with both nail bed and nail matrix psoriasis were included in the study. Full-text Article Dec 2009 Turk Dermatoloji Dergisi. Combined treatment with 8 clobetasol-17-propionate in lacquer applied at the weekend and tacalcitol ointment under occlusion on weekdays for 6 months has shown a good and quick response; response was related to length of therapy. Indian J Dermatol Venereol Leprol 2009;75:119-25. Nail psoriasis can be treated effectively using topical treatments, intralesional treatments, and systemic treatments, but an optimal effect may take up to 1 year. Kavanaugh et al., 2009 133, Kavanaugh et al., 2012 134.
Tacalcitol Ointment For The Treatment Of Nail Psoriasis
Three vitamin D3 analogs are commonly used for the treatment of psoriasis: calcitriol, calcipotriol and tacalcitol. Tacalcitol is a synthetic vitamin D3 analog, which is administered once daily. 60(4), 643659 (2009). Treatment with various creams or ointments can often clear or reduce patches (plaques) of psoriasis. Nail psoriasis may also occur alone without the skin rash. Calcitriol and tacalcitol ointments contain different vitamin D analogues to calcipotriol. Published online: 01 September 2009. It should be noted that some of the topical treatments are messy and difficult to apply. Calcitriol and tacalcitol are less irritant than calcipotriol and may be more suitable for the face or flexures. For efficacy, the proportion of patients whose psoriasis improved was always significantly higher in the two-compound group compared to the group treated with the individual substances. 2009;100(3):190200. 10. Efficacy and safety of Indigo naturalis extract in oil (Lindioil) in treating nail psoriasis: a randomized, observer-blind, vehicle-controlled trial. A study conducted in 2009 revealed that the psychosocial morbidity of psoriasis and impairment of quality of life is the same or worse than arthritis, diabetes or cancer. Bedi noted nail changes in 74 percent of patients with plaque or palmoplantar psoriasis while isolated nail affliction occurred in 6 percent of cases. When it comes to psoriasis, ointment is the most common treatment vehicle because of its soothing effect and occlusive nature. The management of nail psoriasis is reviewed in detail separately. Until 2009, calcipotriene was the only topical vitamin D analog available in the United States. In a systematic review of randomized controlled trials, calcipotriene was at least as effective as potent topical corticosteroids, calcitriol, short contact dithranol, tacalcitol, coal tar and combined coal tar 5, allantoin 2, and hydrocortisone 0.
Nail psoriasis: combined therapy with systemic cyclosporin and topical calcipotriol. 2009Jan. Tacalcitol ointment for the treatment of nail psoriasis. J Dermatolog Treat.