Alleviation of HIV-associated psoriasis and psoriatic arthritis with cyclosporine. 1997 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved. Alleviation of HIV-associated psoriasis and psoriatic arthritis with cyclosporine. Alleviation of HIV-associated psoriasis and psoriatic arthritis with cyclosporin was found in Unbound MEDLINE. Journal of the American Academy of Dermatology 37:3 Pt 1 1997 Sep pg 501-2 MeSH. Cyclosporine.
Treatment of psoriasis associated with human immunodeficiency virus (HIV) infection is challenging because most of the available modalities currently marketed for treatment involve immunosuppression; additionally, the symptomatology in patients with HIV often is more severe and refractory to conventional treatment. Cyclosporine A (CyA) has been used to successfully treat intractable psoriasis in immunocompetent patients, often showing results after conventional therapy has failed.36,37 Cyclosporine A is known to inhibit T-cell activation, thereby reducing the number of CD4 cells while also inhibiting HIV replication by removing the host cell target. Alleviation of HIV-associated psoriasis and psoriatic arthritis with cyclosporine. J Am Acad Dermatol. 1997;37:501-502. Jean Paul; Farber, C. M.; Liesnard, Corinne; Heenen, Michel; Parent, D., 1997: Alleviation of HIV-associated psoriasis and psoriatic arthritis with cyclosporine. Patients with moderate to severe plaque psoriasis (considered here as psoriasis involving more than 5 to 10 percent of the body surface a. Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes. Alleviation of HIV-associated psoriasis and psoriatic arthritis with cyclosporine. J Am Acad Dermatol 1997; 37:501.
The spectrum of rheumatic manifestations of HIV Infection in an era of antiretroviral therapy. 1997;40:S92. 88Tourne, L, Durez, P, Van Vooren, JP et al, Alleviation of HIV-associated psoriasis and psoriatic arthritis with cyclosporine. Up to 40 of patients with psoriasis also develop psoriatic arthritis. That antibody is not present in the blood of patients with psoriatic arthritis. In mid-1997, the United States Food and Drug Administration (FDA) approved the use of tazarotene (Tazorac) to treat mild-to-moderate plaque psoriasis. Methotrexate (MTX) can be given as a pill or as an injection to alleviate symptoms of severe psoriasis or psoriatic arthritis. Hydrocortisone creams have been associated with such side effects as folliculitis (inflammation of the hair follicles), while coal-tar preparations have been associated with a heightened risk of skin cancer.
Psoriasis In The Patient With Human Immunodeficiency Virus, Part 2: Review Of Cutaneous Medicine For The Practitioner
A method for treating psoriatic arthritis comprising administering TNFR:Fc by subcutaneous injection to a patient having psoriatic arthritis, wherein the TNFR:Fc is administered once a week at a dose of 50-100 mg or wherein the TNFR:Fc is administered twice a week at a dose of 25-50 mg. Psoriasis and PsA are different clinical entities, and are associated with somewhat different MHC haplotypes (Gladman, Rheum Dis Clin NA. 1997; Partsch et al., J Rheumatol 25:105-110, 1998; Partsch et al., Ann Rheum Dis 57:691-693, 1998). Psoriatic arthritis is an extracutaneous manifestation that affects at least 5 percent and perhaps as many as 20 percent of patients with psoriasis (Figure 1I). However, because of clinical similarities, psoriasis in patients with HIV infection may be misinterpreted as seborrheic eczema. Moreover, vascular endothelial cells are primed to take part in angiogenesis in psoriasis, and blood vessels that are associated with psoriatic lesions become dilated and contorted, reaching directly beneath the epidermis in the dermal papillar regions (Figure 2B). 30 The response of psoriasis to treatment with compounds that act on lymphocytes, such as cyclosporine, first described for use in psoriasis in 1979, is an early example. Nat Med 1997;3:183-188CrossRef Web of Science Medline. Methotrexate, cyclosporine and retinoids are the most commonly used conventional systemic drugs. Primarily, this increased tissue concentration of adenosine accounts for its anti-inflammatory properties leading to symptom alleviation in psoriasis. Seizures in patients on cyclosporine therapy may be associated with hypomagnesemia or concomitant high-dose corticosteroids. Postmarketing cases of transformation to erythrodermic psoriasis or generalized pustular psoriasis upon either withdrawal or reduction of cyclosporine in patients with chronic plaque psoriasis have been reported. Nephrotoxicity in patients with rheumatoid arthritis treated with cyclosporine. Hivnor C, Nosauri C, James W, Poh-Fitzpatrick M Cyclosporine-induced pseudoporphyria. Psoriatic arthritis (PsA) is a chronic, heterogeneous, inflammatory arthropathy associated with psoriasis. Patients with HIV demonstrate increased incidence of both psoriasis and PsA (Bruce, 2008). Psoriasis is a common inflammatory disease of the skin and joints. Its etiology has been linked to c.