Learn more about Psoriasis: Combinations of topical therapies at aad.org. In fact, one study has shown that the combination of tazarotene and either mid- or high-potency topical corticosteroid is more effective than therapy with tazarotene alone; however, this study did not determine if tazarotene plus topical steroid is superior to topical corticosteroid alone. Tazarotene 0.1 gel plus corticosteroid cream in the treatment of plaque psoriasis. Tazarotene 0.1 gel plus corticosteroid cream in the treatment of plaque psoriasis. Most psoriasis patients are treated with topicals.
Chronic plaque psoriasis, the most common form of psoriasis, is a papulosquamous disease defined by erythematous plaques with a silvery scale. Chronic plaque psoriasis typically is symmetric and bilateral (Figure 1). Topical steroids have been the mainstays of treatment for many years. Topical treatment with vitamin D analogs and corticosteroids is the mainstay of first-line therapy for patients with localized psoriasis. Plaque psoriasis, the most prevalent type of psoriasis, can produce disfiguring, erythem. 39A meta-analysis of 11 randomized, controlled clinical trials compared combination therapy with a vitamin D analog plus a corticosteroid to vitamin D analog monotherapy. Although plaque psoriasis affects roughly two percent of the adult population in the US, most patients with psoriasis have less than five percent of their total body surface area affected. 05 (Clobex Shampoo, Galderma) is also one of the newer options for the effective treatment of scalp psoriasis. Tazarotene 0.1 gel plus corticosteroid cream in the treatment of plaque psoriasis.
Psoriasis, acne vulgaris and photoaging are common conditions. Tazarotene is a pro-drug of tazarotenic acid, a receptor-selective retinoid, which has shown efficacy in the treatment of these disorders. Table 1: Topical corticosteroid combination trials with tazarotene 0.1 gel. Tazarotene 0.1 gel plus corticosteroid cream in the treatment of plaque psoriasis. 0.1 gel plus corticosteroid cream in the treatment of plaque psoriasis. For GRADE evaluation of interventions for Psoriasis (chronic plaque), see table.
Chronic Plaque Psoriasis
The main topical treatments are corticosteroids (in vehicles such as foams, creams, gels, liquids, sprays, or ointments), vitamin D-3 derivatives, coal tar extracts, anthralin, or retinoids (vitamin A analogs). There isn’t one topical drug that is best for all people with psoriasis. UV-B phototherapy is effective for treating moderate-to-severe plaque psoriasis. Learn about steroids and the skin and when they are used to treat inflammatory skin disorders. See the separate Guttate Psoriasis article. It has not been possible to rank efficacy of one topical steroid over another, due to bias and methodology issues with trials in the past. The emollient effect is more prolonged for ointments than creams.